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Guideline
肺癌   LUNG CANCER
原发性支气管肺癌(简称肺癌)是指原发于支气管、肺的恶性肿瘤,是我国最常见的恶性肿瘤之一,其中80-85%为非小细胞肺癌。

在全世界的全部恶性肿瘤死亡病例中,肺癌占19%,居恶性肿瘤死因的首位(WHO 2000)。
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医药新闻
2018年5月
盐酸安罗替尼胶囊属于中国自主研发的创新药,通过优先审评审批程序获准上市,用于治疗晚期或转移性非小细胞肺癌。
2018年4月
2018年3月首次通过美国食品药品管理局新药审批的药物,包括新化学成份和新生物制剂。但未包括暂时审批的药物。药物通过新药审批后可能还需要补充申请批准。
2018年4月
4月12日国务院总理李克强主持召开国务院常务会议,决定对进口抗癌药实施零关税并鼓励创新药进口,顺应民生期盼使患者更多受益。
2018年3月
肺癌预后极差,中国肺癌的5年生存率仅为16.1%。因此,肺癌的早期诊断和早期治疗是提高肺癌生存、降低肺癌死亡率的重要措施。
2018年1月, Elvira Manzano, Roshini Claire Anthony
III期FLAURA试验显示,奥希替尼显著改善无进展生存,优于标准一线治疗。专家们认为该药可能成为EGFR突变阳性晚期非小细胞肺癌(NSCLC)的新治疗标准。
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药物信息

安维汀 AVASTIN  [  罗氏 Roche   ]  贝伐珠单抗 Bevacizumab
适应症: 联合以5-氟尿嘧啶为基础的化疗用于转移性结直肠癌(mCRC);联合卡铂与紫杉醇用于不可切除的晚期、转移性或复发性非鳞状细胞非小细胞肺癌(NSCLC)的一线治疗。
MIMS药理分类 靶向治疗药物 Targeted Cancer Therapy  
Avastin inj soln 100 mg_4 mL0dabf6e0-7bfe-49d4-a15d-9fcb01893f35.GIF
特罗凯 Tarceva  [  罗氏 Roche   ]  厄洛替尼 Erlotinib
适应症: 单药适用于表皮生长因子受体基因具有敏感突变的局部晚期或转移性非小细胞肺癌患者的治疗,包括一线治疗、维持治疗,或既往接受过至少一次化疗进展后的二线及以上治疗。
MIMS药理分类 靶向治疗药物 Targeted Cancer Therapy  
Tarceva coated tab 150 mg3a2783d1-8782-44a2-a7ce-9fcb0189178d.GIF
泰索帝 Taxotere  [  赛诺菲 Sanofi   ]  多西他赛 Docetaxel
适应症: 乳腺癌、非小细胞肺癌、前列腺癌、胃癌。详见产品说明书。
MIMS药理分类 化疗用药 Cytotoxic Chemotherapy  
Taxotere inj soln 20 mg_0.5 mLbb99b5ca-114c-4036-8e16-9fcb0188ab15.GIF
安素泰 Anzatax  [  赫升瑞 Hospira   ]   [  辉瑞投资 Pfizer Inv  ]  紫杉醇 Paclitaxel
适应症: 进展期卵巢癌的一线和后继治疗,非小细胞肺癌的一线治疗。淋巴结阳性乳腺癌的辅助治疗。转移性乳腺癌联合化疗失败或辅助化疗6个月内复发的乳腺癌。AIDS相关性卡波氏肉瘤的二线治疗。
MIMS药理分类 化疗用药 Cytotoxic Chemotherapy  
Anzatax inj soln 30 mg_5 mL7b94e8a0-9afa-4275-9a92-9fcb0188880d.GIF
凯美纳 Conmana  [  贝达药业 BETTA PHARMA   ]  -  盐酸埃克替尼 icotinib hydrochloride
适应症: 单药适用于治疗表皮生长因子受体基因具有敏感突变的局部晚期或转移性非小细胞肺癌患者的一线治疗;或试用于治疗既往接受过至少一个化疗方案失败后的局部晚期或转移性非小细胞肺癌,既往化疗主要是指以铂类为基础的联合化疗。详见说明书。
MIMS药理分类 靶向治疗药物 Targeted Cancer Therapy  
Conmana tab 125 mgab2d0802-3d57-4905-81e1-9fcb01895a92.GIF
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参考文献
  1. 原发性肺癌诊疗规范(2011年版)(一)- 卫生部,全科医学临床与教育,2011年,第9卷第5期,486-489页
  2. 原发性肺癌诊疗规范(2011年版)(二)- 卫生部,全科医学临床与教育,2011年,第9卷第6期,605-608页
  3. 小细胞肺癌的二线化疗及研究进展-肿瘤研究与临床,2006年,第18卷第6期,P424-426(李兰芳 王华庆 )
  4. 循证内科学丛书,呼吸内科-北京科学技术出版社,2010年3月(主编:高占成、胡大一)
  5. 非小细胞肺癌临床实践指南(中国版),2011年第一版( www.nccn.org)
  6. Alberts WM. Diagnosis and management of lung cancer executive summary: ACCP evidence-based clinical practice guidelines (2nd Edition). Chest. 2007 Sep;132(3 Suppl):1S-19S. Accessed 02 Jul 2010. PMID: 17873156
  7. American Cancer Society. Lung cancer (non-small cell). http://www.cancer.org/cancer/lungcancer-non-smallcell/detailedguide/index. Dec 2009. Accessed 07 Feb 2010
  8. American Cancer Society. Lung cancer (small cell). http://www.cancer.org/cancer/lungcancer-smallcell/detailedguide/index. Jun 2010. Accessed 07 Feb 2010
  9. Collins LG, Enck RE, Haines C, et al. Lung cancer: diagnosis and management. Am Fam Physician. 2007 Jan;75(1):56-63. Accessed 02 Jul 2010. PMID: 17225705
  10. D'Addario G, Felip E; ESMO Guidelines Working Group. Non-small-cell lung cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann Oncol. 2008 May;19(Suppl 2):ii39-ii40. doi: 10.1093/annonc/mdn081. Accessed 02 Jul 2010. PMID: 18456762
  11. Eastern Cooperative Oncology Group. ECOG performance status. http://ecog.dfci.harvard.edu/general/perf_stat.html. Accessed 07 Jul 2010
  12. Felip E, Sorensen M. Small-cell lung cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann Oncol. 2008;19:ii41-ii42. Accessed 02 Jul 2010
  13. Glisson BS, Movsas B, Scott W. Small-cell lung cancer, mesothelioma, and thymoma. In: Camhausen KA, Hoskins WJ, Pazdur R, Wagman LD. Cancer Management: a multidisciplinary approach. 12th ed. Nowalk: CMP Healthcare Media LLC; 2009:117-126
  14. Hotta K, Matsuo K, Ueoka H, et al. Role of adjuvant chemotherapy in patients with resected non-small-cell lung cancer: reappraisal with a meta-analysis of randomized controlled trials. J Clin Oncol. 2004 Oct;22(19):3860-3867. PMID: 15326194
  15. Kernstine KH, Khuri FR, Movsas B. Non small-cell lung cancer. In: Camhausen KA, Hoskins WJ, Pazdur R, Wagman LD. Cancer Management: a multidisciplinary approach. 12th ed. Nowalk: CMP Healthcare Media LLC; 2009:71-115
  16. Laurie SA, Logan D, Markaman BR, et al; Lung Cancer Disease Site Group of Cancer Care Ontario's Program in Evidence-based Care. Practice guideline for the role of combination chemotherapy in the initial management of limited-stage small-cell lung cancer. Lung Cancer. 2004 Feb;43(2):223-240. PMID: 14739044
  17. Ministry of Health Singapore. Cancer Screening. MOH clinical practice guideline. MOH (Singapore). http://www.moh.gov.sg/content/dam/moh_web/HPP/Doctors/cpg_medical/current/2010/cpg_Cancer%20Screening%20Booklet%20FINAL%20v6.pdf. Feb 2010. Accessed 02 Jul 2010
  18. National Cancer Institute. Non-small cell lung cancer treatment. http://www.cancer.gov/cancertopics/pdq/treatment/non-small-cell-lung/Patient/page1. Jun 2010. Accessed 05 Jul 2010
  19. National Cancer Institute. Small cell lung cancer treatment. http://www.cancer.gov/cancertopics/pdq/treatment/small-cell-lung/Patient/page1. Jul 2009. Accessed 05 Jul 2009
  20. National Collaborating Centre for Acute Care. The diagnosis and treatment of lung cancer. http://www.nice.org.uk/nicemedia/pdf/cg024niceguideline.pdf. 2005. Accessed 02 Jul 2010
  21. National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: non-small cell lung cancer. Version 3. NCCN. http://www.nccn.org/professionals/physician_gls/pdf/nscl.pdf. 2012. Accessed 15 Oct 2012
  22. National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: small cell lung cancer. Version 2. NCCN. http://www.nccn.org/professionals/physician_gls/pdf/nscl.pdf. 2012. Accessed 15 Oct 2012
  23. Scottish Intercollegiate Guidelines Network. Management of patients with lung cancer: a national clinical guideline. SIGN. http://www.sign.ac.uk/pdf/sign80.pdf. Feb 2005. Accessed 02 Jul 2010
  24. Sheperd FA, rodrigues PJ, Ciuleanu T, eta al; National Cancer Institute of Canada Clinical Trials Group. Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med. 2005 Jul;353(2):123-132. PMID: 16014882
  25. The Hong Kong Anti-cancer Society. Guidelines on cancer prevention, early detection & screening: Lung Cancer. http://www.hkacs.org.hk/uploadimages/download/00143/Guideline%20on%20lung%20cancer%20prevention,%20detection%20&%20screening%20%28full%20recommendation%29.pdf. Nov 2008. Accessed 02 Jul 2010
  26. U.S. Preventive Services Task Force. Lung cancer screening. Recommendation statement. http://www.uspreventiveservicestaskforce.org/uspstf/uspslung.htm. 2004. Accessed 02 Jul 2010
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