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Guideline
血管性认知障碍   VASCULAR COGNITIVE IMPAIRMENT

血管性认知障碍(VCI)是由脑血管病危险因素、显性或非显性脑血管病引起的从轻度认知功能损害(MCI)到血管性痴呆(VD)的一大类综合征。
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为老年期痴呆的第二大病因。

 

随着社会发展和人口的老龄化,脑血管病的发病率逐年升高,血管性痴呆已成为仅次于阿尔茨海默病导致痴呆的第二大病因,严重影响了患者和家属的生活质量,也对社会和家庭造成了沉重的负担。

  查阅疾病用药指南
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药物信息

易倍申 Ebixa  [  灵北 Lundbeck   ]   [  科园信海医药 Keyuan Xinhai Pharm  ]  美金刚 Memantine
适应症: 中重度至重度阿尔茨海默型痴呆。
MIMS药理分类 治疗神经退变性疾病制剂 Neurodegenerative Disease Drugs  
Ebixa filcotab 10 mg85190623-9dc5-4e35-be61-9fcb0189171a.GIF
安理申 Aricept  [  卫材 Eisai   ]  多奈哌齐 Donepezil
适应症: 轻度或中度阿尔茨海默型痴呆症状。
MIMS药理分类 治疗神经退变性疾病制剂 Neurodegenerative Disease Drugs  
Aricept filcotab 10 mg7d40d46e-a204-4180-8123-9fcb01890b98.GIF
阿瑞斯 A Rui Si  [ 方舟制药 ARK Pharm 多奈哌齐 Donepezil
适应症: 轻度或中度阿尔茨海默型痴呆。
MIMS药理分类 治疗神经退变性疾病制剂 Neurodegenerative Disease Drugs  
艾斯能 Exelon  [ 诺华 NOVARTIS 卡巴拉汀 Rivastigmine
适应症: 轻、中度阿尔茨海默型痴呆的症状。
MIMS药理分类 治疗神经退变性疾病制剂 Neurodegenerative Disease Drugs  
喜得镇 Hydergine  [ 诺华 NOVARTIS ]  -  复方甲磺酸二氢麦角碱 co-dergocrine mesylate (dihydroergocryptine mesyla...
适应症: 与老年有关的精神退化,急慢性脑血管疾病后的脑功能衰退。
MIMS药理分类 周围血管扩张药和脑激活剂 Peripheral Vasodilators & Cerebral Activators  
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参考文献
  1. 中国痴呆与认知障碍诊治指南,中华医学会神经病学分会痴呆与认知障碍学组写作组、中国阿尔茨海默病协会(ADC)-人民卫生出版社,2010年11月(主编:贾建平)
  2. 中国痴呆与认知障碍诊治指南:轻度认知障碍的诊断和治疗,中华医学会神经病学分会痴呆与认知障碍学组写作组、中国阿尔茨海默病协会(ADC)-中华医学杂志,2010年11月9日,第90卷第41期,2887-2893页
  3. 神经内科疾病临床诊疗规范教程-北京大学医学出版社,2010年7月(主编:贾建平)
  4. 老年期痴呆防治指南-中华医学会,2007年6月(主编:张明园)
  5. 血管性认知障碍诊治指南,中华医学会神经病学分会痴呆与认知障碍学组写作组 - 中华神经科杂志,2011年2月第44卷第2期,142-147页
  6. Academy of Medicine of Malaysia, Ministry of Health of Malaysia. Clinical practice guidelines for management of dementia. Academy of Medicine of Malaysia. http://www.acadmed.org.my. Jun 2003.
  7. American Psychiatric Association. Practice guideline for the treatment of patients with Alzheimer’s disease and other dementias [2nd ed]. Psychiatryonline. http://www.psychiatryonline.com/pracGuide/PracticePDFs/AlzPG101007.pdf. Oct 2007. Accessed 15 Mar 2011.
  8. Black SE, Doody R, Li H, et al. Donepezil preserves cognition and global function in patients with severe Alzheimer disease. Neurology. 2007 Jul;69(5):459-469. PMID: 17664405
  9. Douglas S, James I, Ballard C. Non-pharmacological interventions in dementia. Adv Psychiatr Treat. 2004;10:171-179
  10. Flicker L, Grimley Evans J. Piracetam for dementia or cognitive impairment. Cochrane Database Syst Rev. 2003(1)
  11. Gorelick PB, Scuteri A, Black SE, et al; American Heart Association Stroke Council, Council on Epidemiology and Prevention, Council on Cardiovascular Nursing, Council on Cardiovascular Radiology and Intervention, and Council on Cardiovascular Surgery and. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association. Stroke. 2011 Sep;42(9):2672-2713. PMID: 21778438
  12. Hachinski V, Iadecola C, Petersen RC, et al. National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards. Stroke. 2006 Sep;37(9):2220-2241. PMID: 16917086
  13. Ministry of Health Singapore. Clinical practice guidelines: dementia. MOH (Singapore). http://www.moh.gov.sg/mohcorp/uploaded Files/Publications/Guidelines/Clinical_Practice_Guidelines/ Dementia.pdf. 2007. Accessed 15 Mar 2011
  14. Moorhouse P, Rockwood K. Vascular cognitive impairment: current concepts and clinical developments. Lancet Neurol. 2008 Mar;7(3):246-255. doi: 10.1016/S1474-4422(08)70040-1. PMID: 18275926
  15. National Collaborating Centre for Mental Health. Dementia: supporting people with dementia and their carers in health and social care. National Clinical Practice guideline No. 42. NICE. http://www.nice.org.uk. 2011. Accessed 05 Apr 2011.
  16. O'Brien JT, Erkinjuntti T, Reisberg B, et al. Vascular cognitive impairment. Lancet Neurol. 2003 Feb;2(2):89-98. PMID: 12849265
  17. Petersen RC, Stevens JC, Ganguli M, et al. Practice parameter: early detection of dementia: mild cognitive impairment (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2001 May;56(9):1133-1142. PMID: 11342677
  18. Roman GC. Rivastigmine for subcortical vascular dementia. Expert Rev Neurother. 2005 May;5(3):309-313. PMID: 15938663
  19. Stephan BC, Matthews FE, Khaw KT, et al. Beyond mild cognitive impairment: vascular cognitive impairment, no dementia (VCIND). Alzheimers Res Ther. 2009 Jul;1(1):4. doi: 10.1186/alzrt4. PMID: 19674437
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