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Guideline
消化不良   DYSPEPSIA
消化不良是一组源自消化道,以持续性或反复发作性上腹部疼痛或烧灼感、餐后上腹饱胀和早饱感等消化道症状为主要表现的症候群。
- 从病因上可分为器质性消化不良(OD)和功能性消化不良(FD),本文侧重介绍后者。

有关消化不良发病率的流行病学资料相对较少,推测年发病率约为1%。
出现消化不良症状的患者中,器质性消化不良仅占少数,多数患者为功能性消化不良。有报道国内功能性消化不良患病率为18-45%。
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洛赛克 Losec  [  阿斯利康 AstraZeneca   ]  奥美拉唑 Omeprazole
适应症: 消化性溃疡出血、吻合口溃疡出血。应激状态时并发的急性胃黏膜损害,非甾体类抗炎药引起的急性胃黏膜损伤。预防重症疾病(如脑出血、严重创伤等)应激状态及胃手术后引起的上消化道出血。作为当口服疗法不适用时下列病症的替代疗法:十二...
MIMS药理分类 抑酸、抗反流和治疗溃疡的药物 Antacids, Antireflux Agents & Antiulcerants  
Losec inj 40 mgbc50dc72-69b5-4cec-8164-9fcb01883784.GIF
洛赛克 MUPS Losec MUPS  [  阿斯利康 AstraZeneca   ]  奥美拉唑 Omeprazole
适应症: 治疗十二指肠溃疡、胃溃疡和反流性食管炎;幽门螺杆菌引起的十二指肠溃疡(联用抗生素);NSAID相关的消化性溃疡或胃十二指肠糜烂;慢性复发性消化性溃疡和反流性食管炎的长期治疗;胃食管反流病的烧心感和反流症状;溃疡样症状及酸...
MIMS药理分类 抑酸、抗反流和治疗溃疡的药物 Antacids, Antireflux Agents & Antiulcerants  
Losec MUPS tab 20 mg8480201a-4e7e-4ea3-98f0-9fcb0188dcfa.GIF
耐信 Nexium  [  阿斯利康 AstraZeneca   ]  埃索美拉唑(艾司奥美拉唑) Esomeprazole
适应症: 胃食管反流病(GERD);与适当的抗菌疗法联合用药根除幽门螺杆菌;需要持续NSAID治疗患者的NSAID相关胃溃疡治疗。
MIMS药理分类 抑酸、抗反流和治疗溃疡的药物 Antacids, Antireflux Agents & Antiulcerants  
Nexium enteric film-coated tab 40 mgca543085-e174-4fa2-8a0b-9fcb0188ef0b.GIF
耐信注射剂 Nexium iv  [  阿斯利康 AstraZeneca   ]  埃索美拉唑(艾司奥美拉唑) Esomeprazole
适应症: 作为当口服疗法不适用时,胃食管反流病的替代疗法,或急性胃或十二指肠溃疡出血的低危患者(胃镜下Forrest分级IIc-III);降低成人胃和十二指肠溃疡出血内镜治疗后再出血风险。
MIMS药理分类 抑酸、抗反流和治疗溃疡的药物 Antacids, Antireflux Agents & Antiulcerants  
Nexium IV powd (parenteral use) 40 mg70f9f5c9-5d7f-425a-b0d9-9fcb01891f3e.GIF
泌特 Mite  [  扬州一洋制药 IL-Yang Pharm   /  百洋医药 BAHEAL ]   [  百洋医药 BAHEAL  ]  -  阿嗪米特 + 纤维素酶 + 二甲硅油 + 胰酶 azintamide + cellulase + dimethicone + pancreatic ...
适应症: 因胆汁分泌不足或消化酶缺乏而引起的症状。
MIMS药理分类 助消化药 Digestives  
Mite enteric film-coated tabb65fd15e-e1ab-4cf0-847a-a06201082264.GIF
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参考文献
  1. 中国消化不良的诊治指南 - 中华医学会消化病学分会胃肠动力学组,中华消化杂志,2007年12月,第27卷第12期:832-834页
  2. 实用内科学(第14版) - 人民卫生出版社,2013年(主编:陈灏珠,林果为,王吉耀)。
  3. 消化病现代治疗 - 上海科技教育出版社,2001年(主编:徐克成,江石湖 )
  4. Chiba N, Van Zanten SJ, Sinclair P, et al. Treating Helicobacter pylori infection in primary care patients with uninvestigated dyspepsia: the Canadian adult dyspepsia empiric treatment-Helicobacter pylori positive (CADET-Hp) randomised controlled trial. BMJ. 2002 Apr;324(7344):101-1016. PMID: 11976244
  5. Delaney BC, Moayyedi P, Forman D. Initial management strategies for dyspepsia [abstract]. Cochrane Database Syst Rev. 2003(2):CD001961. PMID: 12804417
  6. Mc Namara DA, Buckley M, O'Morain CA. Non-ulcer dyspepsia. Current concepts and management. Gastroenterol Clin North Am. 2000 Dec;29(4):807-818. PMID: 11190065
  7. Moayyedi P, Soo S, Deeks L, et al. Pharmacological interventions for non-ulcer dyspepsia [abstract]. Cochrane Database Syst Rev. 2003(1):CD001960. PMID: 12535421
  8. National Institute for Health and Care Excellence. Dyspepsia: Managing dyspepsia in adults in primary care. NICE. http://www.nice.org.uk. Aug 2004
  9. New Zealand Guidelines Group. Management of dyspepsia and heartburn: evidence-based practice guideline. http://www.health.govt.nz/. Jun 2004.
  10. North of England Dyspepsia Guideline Development Group. Dyspepsia: managing dyspepsia in adults in primary care: evidence-based clinical practice guideline. http://www.nice.org.uk/. Aug 2004.
  11. Schroeder BM. Evaluation of epigastric discomfort and management of dyspepsia and GERD. Am Fam Physician. 2003 Sep;68(6):1215-1220. PMID: 14524407
  12. Scottish Intercollegiate Guidelines Network. Dyspepsia. A national clinical guideline. SIGN. http://www.guideline.gov. Mar 2003.
  13. Simren M, Tack J. Functional dyspepsia: evaluation and treatment. Gastroenterol Clin North Am. 2003 Jun;32(2):577-599. PMID: 12858607
  14. Soll AH, Graham DY. Approach to the patient with dyspepsia and peptic ulcer disease. In: Yamada T, Alpers DH, Kalloo AN, eds. Principles of clinical gastroenterology. 1st ed. West Sussex; 2008
  15. Sweetman SC, Blake PS, Brayfield A, et al, eds. Martindale: The complete drug reference [online]. http://www.medicinescomplete.Com
  16. Talley NJ, Silverstein MD, Agréus L, Nyrén O, Sonnenberg A, Holtmann G. AGA technical review: evaluation of dyspepsia. Gastroenterology. 1998 Mar;114(3):582-595. PMID: 9496950
  17. Talley NJ, Vakil N; Practice Parameters Committee of the American College of Gastroenterology. Guidelines for the management of dyspepsia. Am J Gastroenterol. 2005 Oct;100(10):2324-2337. PMID: 16181387
  18. Talley NJ. Therapeutic options in nonulcer dyspepsia. J Clin Gastroenterol. 2001 Apr;32(4):286-293. PMID: 11276271
  19. Talley NJ. Update on the role of drug therapy in non-ulcer dyspepsia. Rev Gastroenterol Disord. 2003;3(1):25-30. PMID: 12684590
  20. Wickersham RM, Schweain SL, Scott JA, eds. Drug facts and comparisons. http://www.factsandcomparisons.com/drug-information-references.aspx
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