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Guideline
男性性腺功能减退症和勃起功能障碍   HYPOGONADISM IN MALES - LATE-ONSET & ERECTILE DYSFUNCTION
男性迟发性性腺功能减退症(Late-Onset Hypogonadism,LOH)是一种与年龄增长相关的、具有性功能障碍症状和血清睾酮水平降低的综合征,对患者的生活质量,多种器官、系统的功能均有不良影响。
- 勃起功能障碍是其主要症状之一。
勃起功能障碍(Erectile Dysfunction,ED)是指阴茎不能达到和维持足以进行满意性交的勃起,病程超过3个月。
- 按病因可分为心理性、器质性(血管、神经、内分泌、某些药物所致)和混合性三大类。

雄激素缺乏随年龄而加重,中年男性发病率可达6%。本病在老年、肥胖、合并症较多、体质较弱者中发病更为普遍。
ED患病率随年龄增加而升高。根据我国部分地区的问卷调查,ED患病率为28.33%,≥40岁男性的患病率为40.20%。
  查阅疾病用药指南
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医药新闻
2016年9月, Kavitha G. Shekar
睾酮治疗可提高≥65岁男性的性功能,改善心情,减轻抑郁症状。但未能改善活力和步行距离。
2016年9月
中国中西医结合学会难看专业委员会参照英国牛津大学循证医学中心对循证级别提出的分类方法,参考国内外最新指南及研究成果制定了《勃起功能障碍中西医结合诊疗指南(试行版)》。
2015年12月, Roshini Claire Anthony
利用药物或装置的阴茎复健可恢复前列腺癌治疗后的勃起功能,陈笃生医院泌尿科,男科主任,Ronny Tan医生最近在前列腺宣传月活动期间的一次谈话时说道。
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药物信息

希爱力 Cialis  [ 礼来 Eli Lilly 他达拉非 Tadalafil
适应症: 男性勃起功能障碍。
MIMS药理分类 勃起与射精功能障碍用药 Drugs for Erectile Dysfunction & Ejaculatory Disorders  
艾力达 Levitra  [ 拜耳医药保健 Bayer HealthCare 伐地那非 Vardenafil
适应症: 阴茎勃起功能障碍。
MIMS药理分类 勃起与射精功能障碍用药 Drugs for Erectile Dysfunction & Ejaculatory Disorders  
万艾可 VIAGRA  [ 辉瑞制药 Pfizer Pharm 西地那非 Sildenafil
适应症: 勃起功能障碍。
MIMS药理分类 勃起与射精功能障碍用药 Drugs for Erectile Dysfunction & Ejaculatory Disorders  
安挺 AnTing
MIMS药理分类 其他降压药 Other Antihypertensives   /   勃起与射精功能障碍用药 Drugs for Erectile Dysfunction & Ejaculatory Disorders  
比法尔 Bi Fa Er
MIMS药理分类 勃起与射精功能障碍用药 Drugs for Erectile Dysfunction & Ejaculatory Disorders  
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参考文献
  1. 实用内科学(第13版) - 人民卫生出版社,2009年(主编:陈灏珠)
  2. 男性性功能障碍诊治框架 - 中华男科学杂志,2005.11(9):713-715,719(朱积川,许清泉)
  3. American Association of Clinical Endocrinologists. American Association of Clinical Endocrinologists medical guidelines for clinical practice for the evaluation and treatment of male sexual dysfunction: a couple's problem -2003 update. Endocr Pract. 2003 Jan;9(1):77-95. PMID: 12917096
  4. American Urological Association Education and Research, Inc. Management of erectile dysfunction [chapter 1 w/ appendix: diagnosis and treatment guideline]. http://www.auanet.org/education/guidelines/erectile-dysfunction.cfm. 2005
  5. Bhasin S, Cunningham GR, Hayes FJ, et al. Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2006 Jun;91(6):1995-2010. PMID: 16720669
  6. Bolona ER, Uraga MV, Haddad RM, et al. Testosterone use in men with sexual dysfunction: a systematic review and meta-analysis of randomized placebo-controlled trials. Mayo Clin Proc. 2007 Jan;82(1):20-28. PMID: 17285782
  7. Haddad RM, Kennedy CC, Caples SM, et al. Testosterone and cardiovascular risk in men: a systematic review and meta-analysis of randomized placebo-controlled trials. Mayo Clin Proc. 2007 Jan;82(1):29-39. PMID: 17285783
  8. Hatzimouratidis K, Amar E, Eardley I,et al; European Association of Urology. Guidelines on male sexual dysfunction: erectile dysfunction and premature ejaculation. Eur Urol. 2010 May;57(5):804-814. doi: 10.1016/j.eururo.2010.02.020. PMID: 20189712
  9. International Society of Andrology, International Society for the Study of the Aging Male, European Association of Urology. Investigation, treatment and monitoring of late-onset hypogonadism in males. http://www.uroweb.org/fileadmin/user_upload/Guidelines/14%20Hypogonadism.pdf. Jun 2006
  10. Kim YC. Hormonal replacement therapy and aging: Asian practical recommendations on testosterone supplementation. Asian J Androl. 2003 Dec;5(4):339-344. PMID: 14695985
  11. Malaysia Urological Association and MEDACT. Clinical Practice Guide in Erectile Dysfunction. www.acadmed.org.my/view_file.cfm?fileid=211. Aug 2000
  12. Montorsi F, Salonia A, Deho F, et al. Pharmacological management of erectile dysfunction. BJU Int. 2003 Mar;91(5):446-454. PMID: 12603396
  13. Morales A, Lunenfeld B; International Society for the Study of the Aging Male. Investigation, treatment and monitoring of late-onset hypogonadism in males. Official recommendations of ISSAM. International Society for the Study of the Aging Male. Aging Male. 2002 Jun;5(2):74-86. PMID: 12198738
  14. Petak SM, Nankin HR, Spark RF, et al. American Association of Clinical Endocrinologists Medical Guidelines for clinical practice for the evaluation and treatment of hypogonadism in adult male patients - 2002 update. Endocr Pract. 2002 Nov;8(6):439-456. PMID: 15260010
  15. Singapore Urological Association. Andropause guidelines. http://www.sua.org.sg/. Oct 2006
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