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Guideline
感染性心内膜炎   INFECTIVE ENDOCARDITIS
感染性心内膜炎(IE)是指心瓣膜或心腔壁内膜由于致病微生物(如细菌、真菌、病毒)侵入引起感染性炎症,主要病理特征是心瓣膜上赘生物形成并伴有菌血症。
- 本文侧重介绍细菌性心内膜炎。
  查阅疾病用药指南
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医药新闻
2015年4月
2015年4月1 - 15日首次通过美国食品药品管理局(FDA)新药审批的药物,包括新化学成份和新生物制剂。但未包括暂时审批的药物。药物通过新药审批后可能还需要补充申请批准。
2014年10月
中华医学会心血管病学分会,心力衰竭学组对近几年国内外主要的感染性心内膜指南及国内外相关的研究资料进行了分析和回顾,评估了各种诊断和治疗方法的证据与推荐等级,编制了我国首部成人感染性心内膜共识。
2014年7月, Saras Ramiya

最新发布的风湿性心脏病(RHD)控制计划实施方法(TIPS)指南将为全球风湿性心脏病控制计划的实施提供帮助。

2013年8月
本研究通过统计感染性心内膜炎患者血培养分离鉴定的致病菌,分析了其致病菌的分布及其对常见抗菌药物的敏感性。
2013年5月
本研究纳入85例诊断为感染性心内膜炎的患者作为病例组,抽取90例无心脏病史人群做对照组,探讨超声心动图对感染性心内膜炎的诊断价值。
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药物信息

可乐必妥 Cravit  [  第一三共 Daiichi-Sankyo   /  第一三共(中国) Daiichi-Sankyo (China) 左氧氟沙星 Levofloxacin
适应症: 敏感菌所引起医院/社区获得性肺炎、急性细菌性鼻窦炎、慢性支气管炎的急性细菌性发作、复杂性皮肤及皮肤结构感染、非复杂性皮肤及皮肤软组织感染、慢性细菌性前列腺炎、复杂性尿路感染、急性肾盂肾炎、非复杂性尿路感染、吸入性炭疽(暴...
MIMS药理分类 喹诺酮类 Quinolones  
Cravit filcotab 500 mg845fc148-76b9-4ebc-a596-9fcb018874ed.GIF
克必信 Cubicin  [  阿斯利康 AstraZeneca   ]   [  默沙东 MSD  ]  -  达托霉素 daptomycin
适应症: 对本品敏感的金黄色葡萄球菌(包括MRSA)、化脓链球菌、无乳链球菌、停乳链球菌似马亚种及粪肠球菌(仅用于万古霉素敏感菌株)导致的复杂性皮肤及软组织感染。金黄色葡萄球菌(包括甲氧西林敏感和耐药)血流感染(菌血症),及伴发的...
MIMS药理分类 其他抗生素 Other Antibiotics  
Cubicin powd (parenteral use) 0.5 gd396af69-abac-424a-a4ea-9fcb01886db0.GIF
泰能 Tienam  [  默沙东 MSD   ]  亚胺培南+西司他丁 Imipenem + Cilastatin
适应症: 敏感细菌所引起腹腔内、下呼吸道、妇科、泌尿生殖道、骨关节、皮肤软组织感染,败血症,心内膜炎。
MIMS药理分类 其他 β-内酰胺类 Other Beta-Lactams  
Tienam IV infusion 0.5 g_0.5 gba2b49b0-7bc7-4a11-8f16-9fcb0188bf59.GIF
克倍宁 CARBENIN  [  第一三共 Daiichi-Sankyo   /  第一三共(中国) Daiichi-Sankyo (China) ]  -  倍他米隆 + 帕尼培南 betamipron + panipenem
适应症: 敏感菌引起的败血症,感染性心内膜炎,深部皮肤感染症、淋巴管(结)炎,肛周脓肿,外伤、烧伤及手术后继发感染、骨髓炎、关节炎,呼吸系统、泌尿和生殖系统、腹腔感染,子宫附件炎、子宫内感染、子宫旁组织炎、前庭大腺炎,化脓性脑膜炎...
MIMS药理分类 其他 β-内酰胺类 Other Beta-Lactams  
Carbenin powd (parenteral use) 0.5 g18a8a034-4f78-4fe6-8d82-a084009b0d8f.GIF
先锋美他醇 CEFMETAZON  [  第一三共 Daiichi-Sankyo   ]  头孢美唑 Cefmetazole
适应症: 敏感菌引起的败血症;呼吸系统感染;胆管炎,胆囊炎;腹膜炎;肾盂肾炎,膀胱炎;子宫附件炎、子宫内感染、子宫旁组织炎、前庭大腺炎;盆腔炎;颌骨周围蜂窝织炎,颌炎。
MIMS药理分类 头孢菌素类 Cephalosporins  
Cefmetazon powd (parenteral use) 1 ge5249a15-da04-46a4-aa09-9fcb0188cdb5.GIF
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参考文献
  1. 万古霉素临床应用中国专家共识(2011版)- 中国新药与临床杂志,2011年8月,第30卷第8期;561-573页
  2. 临床诊疗指南,心血管分册-人民卫生出版社,2009年(编著:中华医学会)
  3. 心血管内科诊疗精要 - 中南大学出版社, 2011(主编:赵水平、李江)
  4. 抗菌药物临床应用指导原则 - 中华医学会,中华医院管理学会药事管理专业委员会,中国药学会医院药学专业委员会,中华医学杂志,2004年第84卷第22,23期
  5. Baddour LM, Wilson WR, Bayer AS, et al. Infective endocarditis: diagnosis, antimicrobial therapy, and management of complications: a statement for healthcare professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young,. Circulation. 2005 Jun;111(23):e394-e434. http://www.ncbi.nlm.nih.gov/pubmed/?term=15956145. PMID: 15956145
  6. Brouqui P, Raoult D. Endocarditis due to rare and fastidious bacteria. Clin Microbiol Rev. 2001 Jan;14(1):177-207. PMID: 11148009
  7. Brown PD, Levine DP. Infective endocarditis in the injection drug user. Infect Dis Clin North Am. 2002 Sep;14(3):645-665, viii-ix. PMID: 12371120
  8. Crawford MH, Durack DT. Clinical presentation of infective endocarditis. Cardiol Clin. 2003 May;21(2):159-166. PMID: 12874890
  9. Ferrieri P, Gewitz MH, Gerber MA, et al. Unique features of infective endocarditis in childhood. Circulation. 2002 Apr;105(17):2115-2126. PMID: 11980694
  10. Giessel BE, Koenig CJ, Blake RL Jr. Management of bacterial endocarditis. Am Fam Physician. 2000 Mar;61(6):1725-1732,1739. PMID: 10750879
  11. Habib G, Hoen B, Tornos P, et al; ESC Committee for Practice Guidelines. Guidelines on the prevention, diagnosis, and treatment of infective endocarditis (new version 2009): the Task Force on the Prevention, Diagnosis, and Treatment of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) and the International Society of Chemotherapy (ISC) for Infection and Cancer. Aug 27, 2009. Eur Heart J. 2009 Oct;30(19):2369-2413. http://www.ncbi.nlm.nih.gov/pubmed/?term=19713420. PMID: 19713420
  12. Harris GD, Steimle J. Compiling the identifying features of bacterial endocarditis. Vague clues may point to this dangerous infection. Postgrad Med. 2000 Jan;107(1):75-83. http://www.ncbi.nlm.nih.gov/pubmed/?term=10649666. PMID: 10649666
  13. Horstkotte D, Follath F, Gutschik E, et al;Task Force Members on Infective Endocarditis of the European Society of Cardiology; ESC Committee for Practice Guidelines (CPG). Guidelines on prevention, diagnosis and treatment of infective endocarditis executive summary; the task force on infective endocarditis of the European Society of Cardiology. Eur Heart J. 2004 Feb;25(3):267-276. http://www.ncbi.nlm.nih.gov/pubmed/?term=14972429. PMID: 14972429
  14. Jassal DS, Embil M. CME workshop - infective endocarditis: prophylaxis, diagnosis and management. Can J CME. 2002 Feb;14:33-48. http://www.stacommunications.com/journals/cme/2002/02-Feb/cmefeb02Workshop.pdf
  15. Keys TF. The Cleveland Clinic Disease Management Project: infective endocarditis. http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/infectious-disease/infective-endocarditis/. Aug 2010
  16. Li JS, Sexton DJ, Mick N, et al. Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis. Clin Infect Dis. 2000 Apr;30(4):633-638. PMID: 10770721
  17. Malaysian Society of Infectious Diseases and Chemotherapy, Academy of Medicine of Malaysia, Ministry of Health Malaysia. Consensus guidelines on the management of Staphylococcus aureus infections. http://www.acadmed.org.my/view_file.cfm?fileid=202. Mar 2000.
  18. Marill, K. Endocarditis. eMedicine. http://www. emedicine.com/emerg/topic164.htm. 2004
  19. Mylonakis E, Calderwood SB. Infective endocarditis in adults. N Engl J Med. 2001 Nov;345(18):1318-1330. PMID: 11794152
  20. Nishimura RA, Carabello BA, Faxon DP, et al. ACC/AHA 2008 guideline update on valvular heart disease: focused update on infective endocarditis: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines: endorsed by the Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. Jul 28, 2008. Circulation. 2008 Aug;118(8):887-896. http://www.ncbi.nlm.nih.gov/pubmed/18663090. PMID: 18663090
  21. Prendergast BD. Diagnosis of infective endocarditis. BMJ. 2002 Oct;325(7369):845-846. PMID: 12386011
  22. Sachdev M, Peterson GE, Jollis JG. Imaging techniques for diagnosis of infective endocarditis. Infect Dis Clin North Am. 2002 Jun;16(2):ix,319-337. PMID: 12092475
  23. Wilson W, Taubert KA, Gewitz M, et al; American Heart Association Rheumatic Fever, Endocarditis and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young; Council on Clinical Cardiology; Council on Cardiovascular Surgery and Anesthesi. Prevention of infective endocarditis: guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever, Endocarditis and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Cou. J Am Dent Assoc. 2007 Jun;138(6):739-760. PMID: 17545263
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Society for Emergency Medicine in Singapore Annual Scientific Meeting / International Resuscitation Science Symposium 27th-28th February 2016
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